Driven to action by the unprecedented global devastation of the COVID-19 pandemic, Steve and Nina Goodale center their community advocacy on the guiding principle that transparency, accountability and integrity are inextricably linked with their activism. Their commitment to a comprehensive global biosafety objective includes rigorous fact finding investigations to determine COVID-19’s origins as a pathway to optimizing biosafety, biosecurity and biorisk management for public and environmental health and safety. As the COVID-19 pandemic also accelerated the proliferation of private, commercial biolabs in Silicon Valley’s densely populated, seismically and environmentally vulnerable neighborhoods, the Goodales made a surprising discovery that local biosafety regulations were largely absent because policymakers tended to rely on guidance from vested life science lobbyists. Drawing from their combined Ed-tech and legal advocacy backgrounds combined with their passion for environmental conservation and sustainability, their dynamic efforts include educating city officials and community groups on the critical regulatory gaps in biosafety, biosecurity and biorisk management, monitoring and oversight—the very gaps which evidently contributed to the COVID-19 pandemic. In close collaboration with their local Sierra Club, the Goodales formed a biosafety working group, the efforts of which culminated in a webinar that featured expert panelists and intended to educate municipal leaders and community advocates not only on the benefits but also the unique risks inherent in life science land use policy, planning and development.